Pan, Jolyn; Lian, Kjersti; Sarre, Aili; Leiros, Hanna-Kirsti Schrøder; Williamson, Adele Kim (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-21)
DNA ligases, the enzymes responsible for joining breaks in the phosphodiester backbone of DNA during replication and repair, vary considerably in size and structure. The smallest members of this enzyme class carry out their functions with pared-down protein scaffolds comprising only the core catalytic domains. Here we use sequence similarity network analysis of minimal DNA ligases from all biological ...